Influence of the injection technique on the thermal degradation of cocaine and its metabolites in gas chromatography
作者： M.L. González , M. Carnicero , R. de la Torre , J. Ortuño , J. Segura
DOI: 10.1016/0378-4347(94)00484-M
关键词:
摘要: Thermal degradation of some substances due to high temperature at the injection port and/or type technique used may limit usefulness gas chromatography with conventional detectors or coupled mass spectrometry. To minimize thermal cocaine and its metabolites, was performed using two different insert liners a cool on-column inlet. When packed liner, marked all compounds observed. The process reduced by use an open liner and, when inlet employed, essentially no occurred.
elsevier.com
sci-hub.se 参考文章(16)
R. Martin Smith, Ethyl Esters of Arylhydroxy- and Arylhydroxymethoxycocaines in the Urines of Simultaneous Cocaine and Ethanol Users Journal of Analytical Toxicology. ,vol. 8, pp. 38- 42 ,(1984) , 10.1093/JAT/8.1.38
Satya P. Jindal, Theresa Lutz, Mass Spectrometric Studies of Cocaine Disposition in Animals and Humans Using Stable Isotope-Labeled Analogues Journal of Pharmaceutical Sciences. ,vol. 78, pp. 1009- 1014 ,(1989) , 10.1002/JPS.2600781208
R de la Torre, ML González, J Ortuño, J Camí, M Farré, J Segura, None, Thermal Degradation of Cocaine and Its Metabolites in Gas Chromatography. A Source of Errors When Interpreting Metabolic Results Therapeutic Drug Monitoring. ,vol. 15, pp. 165- ,(1993) , 10.1097/00007691-199304000-00126
J. Ortuño, R. De La Torre, J. Segura, J. Camí, Simultaneous detection in urine of cocaine and its main metabolites. Journal of Pharmaceutical and Biomedical Analysis. ,vol. 8, pp. 911- 914 ,(1990) , 10.1016/0731-7085(90)80141-B
Peyton Jacob, Barbara A. Elias-Baker, Reese T. Jones, Neal L. Benowitz, Determination of benzoylecgonine and cocaine in biologic fluids by automated gas chromatography. Journal of Chromatography A. ,vol. 417, pp. 277- 286 ,(1987) , 10.1016/0378-4347(87)80121-4
Bridget F. Grant, Thomas C. Harford, Concurrent and simultaneous use of alcohol with cocaine: results of national survey. Drug and Alcohol Dependence. ,vol. 25, pp. 97- 104 ,(1990) , 10.1016/0376-8716(90)90147-7
P Jatlow, H Nadim, Determination of Cocaine Concentrations in Plasma by High-Performance Liquid Chromatography Clinical Chemistry. ,vol. 36, pp. 1436- 1439 ,(1990) , 10.1093/CLINCHEM/36.8.1436
S.J. Mulé, G.A. Casella, Confirmation and quantitation of cocaine, benzoylecgonine, ecgonine methyl ester in human urine by GC/MS. Journal of Analytical Toxicology. ,vol. 12, pp. 153- 155 ,(1988) , 10.1093/JAT/12.3.153
Ji Yue Zhang, Rodger L. Foltz, Cocaine Metabolism in Man: Identification of Four Previously Unreported Cocaine Metabolites in Human Urine Journal of Analytical Toxicology. ,vol. 14, pp. 201- 205 ,(1990) , 10.1093/JAT/14.4.201
R De La Torre, M Farre, J Ortuno, J Cami, J Segura, The Relevance of Urinary Cocaethylene following the Simultaneous Administration of Alcohol and Cocaine Journal of Analytical Toxicology. ,vol. 15, pp. 223- 223 ,(1991) , 10.1093/JAT/15.4.123