Total IgE and allergen-specific IgE and IgG antibody levels in sera of atopic dermatitis affected and non-affected Labrador- and Golden retrievers.
作者： Beatrice Lauber , Vivianne Molitor , Sabrina Meury , Marcus G. Doherr , Claude Favrot
DOI: 10.1016/J.VETIMM.2012.05.018
关键词:
摘要: Canine atopic dermatitis (CAD) is an allergic skin disease associated with IgE and IgG antibodies (Ab) to environmental allergens. The aim of this study was determine which other factors influence serum Ab levels in CAD-affected non-affected dogs as has only been poorly investigated so far. Total allergen-specific Dermatophagoides farinae (DF)-specific IgG1 IgG4 were measured by ELISA sera 145 271 Labrador- Golden retrievers. A multivariable logistic regression analysis including the age, breed, gender, castration, clinical CAD status immunotherapy (ASIT) performed. retrievers had more frequently total (OR=1.87, 95% CI=1.26-2.87, p<0.01) specific above threshold value than Labrador retrievers, suggesting that genetic dogs. Castration generally low (OR=0.43-0.65, p<0.05). Surprisingly, did not have increased odds for high against any allergens tested. ASIT DF DF-specific (OR=4.32, CI 1.46-12.8, but or decreased levels. Further studies are needed understand role ASIT.
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