Molecular Characterization by Immunocytochemistry of Lung Adenocarcinoma on Cytology Specimens

摘要: The discovery of targetable driver mutations in pulmonary adenocarcinoma has revolutionized the field thoracic oncology by introduction oral small molecule tyrosine kinase inhibitors that target specific EGFR and EML-4/ALK rearrangement. Therefore, testing for gene ALK rearrangements become part everyday clinical practice. majority lung cancer patients present at an advanced stage, where biopsy cytology specimens are often only available material diagnostic workup molecular characterization. Mutation standard care. Nonetheless, technical complexity relative high cost test have challenged widespread use techniques settings. Recently, antibodies to alterations potential instruments characterization tumors. In this review article we will discuss practical issues on immunocytochemical stains detection mutant protein as alternative or adjunct techniques.