Myocardial ischemia enhances the expression of acidic fibroblast growth factor in human pericardial fluid.
作者： Atsushi Iwakura , M. Fujita , Masaki Ikemoto , Koji Hasegawa , Ryuji Nohara
DOI: 10.1007/PL00007264
关键词:
摘要: Acidic fibroblast growth factor (FGF) is a potent mitogen that can induce angiogenesis in vivo. We have recently reported marked increase of basic FGF the pericardial fluid patients with severe coronary stenosis and an vascular endothelial (VEGF) myocardial ischemia. The purpose this study was to evaluate whether acidic levels are associated Immediately after incision pericardium 48 during open-heart surgery, 3–5 ml obtained. Concentrations VEGF were measured using enzyme-linked immunosorbent assay (ELISA). ELISA system for human newly developed rabbit antibovine antibody. divided into three groups (group A: 13 undergoing emergency artery bypass grafting (CABG) unstable angina; group B: 17 elective CABG stable C: 18 nonischemic surgery). level A 68 ± 59 pg/ml, which significantly higher than 33 9 pg/ml B 31 20 C (P < 0.05). concentrations 722 601 773 763 respectively, 263 349 C. 4 291 2 336 also 386 1 048 589 990 correlated well (r = 0.61, P 0.0001). It concluded This result indicates release from tissue closely related
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