Gastric juice nitrite and vitamin C in patients with gastric cancer and atrophic gastritis: is low acidity solely responsible for cancer risk?

摘要: Background N-nitroso compounds are carcinogens formed from nitrite, a process that is inhibited by vitamin C in gastric juice. Helicobacter pylori infection has been reported to increase nitrite and decrease Therefore, susceptibility cancer H. pylori-infected patients may be derived increased However, most do not develop cancer. Objective To investigate additional factors affect cancer, we compared levels juice with without Methods Serum were obtained 95 undergoing diagnostic endoscopy, including those normal findings, duodenal ulcer, atrophic gastritis was analysed for antibody, nitrate gastrin pepsinogens; pH, C. Results pH decreased the of other patients. similar acidity (pH 5-8), concentrations significantly higher lower than gastritis. Conclusion Although hypochlorhydria increases intraluminal decreases C, which formation compounds, our results indicate have emphasize these changes.