摘要: Once only a subject for science fiction novels, plans establishing habitation on space stations, the Moon, and distant planets now appear among short-term goals of agencies. This article reviews studies that present biomedical issues to challenge humankind long-term spaceflights. With particularly focus cells bone marrow origin, involving changes in bone, immune, red blood cell populations their functions due extended weightlessness were reviewed. Furthermore, effects mechanical disuse primitive stem reside also included this review. Novel solutions using biotechnology will be required order achieve goal exploration without compromising marrow, as spaceflight appears disrupt homeostasis all given types. Conflict interest:None declared.