No association of the MDM2 SNP309 polymorphism with risk of breast or ovarian cancer.
作者： Ian G Campbell , Diana M Eccles , David Y.H. Choong
DOI: 10.1016/J.CANLET.2005.09.003
关键词:
摘要: A functional T to G germline polymorphism in the promoter region of MDM2 (SNP309) has been reported profoundly accelerate tumor formation suggesting that it may also represent a powerful cancer predisposing allele. To investigate role SNP309 predisposition we undertook case-control study this among 351 women diagnosed with breast cancer, 302 ovarian and 258 female controls from British population. The GG genotype was not associated either (OR 1.04, 95% CI 0.67-1.60) or 0.86, 0.53-1.37). This found no evidence is early onset familial cancer.
elsevier.com
sci-hub.se 参考文章(7)
DM Eccles, P Englefield, MA Soulby, IG Campbell, BRCA1 mutations in southern England. British Journal of Cancer. ,vol. 77, pp. 2199- 2203 ,(1998) , 10.1038/BJC.1998.366
WD Foulkes, GWH Stamp, S Afzal, N Lalani, CP McFarlane, J Trowsdale, IG Campbell, MDM2 overexpression is rare in ovarian carcinoma irrespective of TP53 mutation status. British Journal of Cancer. ,vol. 72, pp. 883- 888 ,(1995) , 10.1038/BJC.1995.428
D Eccles, A Marlow, G Royle, A Collins, N E Morton, Genetic epidemiology of early onset breast cancer. Journal of Medical Genetics. ,vol. 31, pp. 944- 949 ,(1994) , 10.1136/JMG.31.12.944
Carlos E. Bueso-Ramos, Taghi Manshouri, Mohammad A. Haidar, Yun Yang, Patrick McCown, Nelson Ordonez, Armand Glassman, Nour Sneige, Maher Albitar, Abnormal expression of MDM-2 in breast carcinomas Breast Cancer Research and Treatment. ,vol. 37, pp. 179- 188 ,(1996) , 10.1007/BF01806499
J. D. Oliner, K. W. Kinzler, P. S. Meltzer, D. L. George, B. Vogelstein, Amplification of a gene encoding a p53-associated protein in human sarcomas Nature. ,vol. 358, pp. 80- 83 ,(1992) , 10.1038/358080A0
Gareth L. Bond, Wenwei Hu, Elisabeth E. Bond, Harlan Robins, Stuart G. Lutzker, Nicoleta C. Arva, Jill Bargonetti, Frank Bartel, Helge Taubert, Peter Wuerl, Kenan Onel, Linwah Yip, Shih-Jen Hwang, Louise C. Strong, Guillermina Lozano, Arnold J. Levine, A single nucleotide polymorphism in the MDM2 promoter attenuates the p53 tumor suppressor pathway and accelerates tumor formation in humans. Cell. ,vol. 119, pp. 591- 602 ,(2004) , 10.1016/J.CELL.2004.11.022
K Lundgren, R Montes de Oca Luna, Y B McNeill, E P Emerick, B Spencer, C R Barfield, G Lozano, M P Rosenberg, C A Finlay, Targeted expression of MDM2 uncouples S phase from mitosis and inhibits mammary gland development independent of p53. Genes & Development. ,vol. 11, pp. 714- 725 ,(1997) , 10.1101/GAD.11.6.714