The Impact of Appetite-Regulating Neuropeptide Leptin on Alcohol Use, Alcohol Craving and Addictive Behavior: A Systematic Review of Preclinical and Clinical Data

摘要: AIMS The appetite regulating hormone leptin, which is mainly secreted from adipose tissue, an important regulator of food intake and modulator reward-driven behavior. Leptin exerts its biological actions via binding to the leptin receptor, expressed in hypothalamus, but also hippocampus, amygdala substantia nigra. In ventral tegmental area (VTA), attenuates firing rate dopaminergic neurons that project Nucleus accumbens (NAc), serves as relay other brain areas "addiction network", such prefrontal cortex. This suggests plays a role processing rewards context substance use disorders alcohol disorder, especially through attenuation activity mesolimbic reward system. supports plausibility leptin's potential effects disorder. METHODS We searched MEDLINE 1990 February 2020. All abstracts were screened for relevance we only included publications reporting original data with full text available English language. Studies did not report leptin-data, reviews or case reports/series included. RESULTS identified total N=293 studies whom N=55 preclinical clinical met specified criteria. N=40 investigated on plasma levels, N=9 craving N=6 relapse consumption. CONCLUSIONS this review data, assess development maintenance relapse. Integrating existing may reveal new innovative targets treatment future.