The Prevotella copri Complex Comprises Four Distinct Clades Underrepresented in Westernized Populations
作者： Adrian Tett , Kun D. Huang , Francesco Asnicar , Hannah Fehlner-Peach , Edoardo Pasolli
DOI: 10.1016/J.CHOM.2019.08.018
关键词:
摘要: Prevotella copri is a common human gut microbe that has been both positively and negatively associated with host health. In a cross-continent meta-analysis exploiting> 6,500 metagenomes, we obtained> 1,000 genomes and explored the genetic and population structure of P. copri. P. copri encompasses four distinct clades (> 10% inter-clade genetic divergence) that we propose constitute the P. copri complex, and all clades were confirmed by isolate sequencing. These clades are nearly ubiquitous and co-present in non …
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