CBX3 promotes colon cancer cell proliferation by CDK6 kinase-independent function during cell cycle
作者： Yao Fan , Haiping Li , Xiaolong Liang , Zheng Xiang
DOI: 10.18632/ONCOTARGET.15253
关键词:
摘要: // Yao Fan 1, 2 , Haiping Li Xiaolong Liang Zheng Xiang 1 Chongqing Key Laboratory of Department General Surgery, Medical University, Chongqing, China Gastrointestinal The First Affiliated Hospital Correspondence to: Xiang, email: 13330209937@163.com Keywords: colon cancer, CBX3, CDK6, p21, proliferation Received: August 01, 2016 Accepted: December 12, Published: February 10, 2017 ABSTRACT Heterochromatin protein 1γ (CBX3) links histone methylation marks to transcriptional silence, DNA repair and RNA splicing, but a role for CBX3 in cancer remains largely unknown. In this study, we show that cells promotes the progression cell cycle vitro vivo . Cell (G1 phase S phase) related gene CDK6 p21 were further identified as targets CBX3. addition, found enhancing suppresses by upregulating inhibitor absence function is independent kinase activity CDK6. Our results demonstrate key carcinogenesis via suppressing expression CDK6/p21, which may disrupt transcriptionally regulating part negative feedback loop limit excessive activation.
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