Fucosylated Human Milk Oligosaccharides and N-Glycans in the Milk of Chinese Mothers Regulate the Gut Microbiome of Their Breast-Fed Infants during Different Lactation Stages.

摘要: ABSTRACT The milk glycobiome has a significant impact on the gut microbiota of infants, which plays pivotal role in health and development. Fucosylated human oligosaccharides (HMOs) N-glycans proteins are beneficial for development healthy microbiota, fucosylation levels these glycans can be affected by maternal fucosyltransferase 2 gene (FUT2). Here, we present results longitudinal research paired stool samples from 56 Chinese mothers (CMs) their breast-fed children. Changes HMOs fucosylated CMs at different lactation stages were detected, allowed characterization major differences consequential effects microbiome infants according to FUT2 status. Significant abundance total between secretor nonsecretor noted, especially during early lactation. Despite tendency toward decreasing protein concentrations, increased late changes highly correlated with growth Bifidobacterium spp. Lactobacillus later lactation, respectively. Enriched expression genes encoding glycoside hydrolases, glycosyl transferases, ATP-binding cassette (ABC) transporters, permeases fed contributed promotion bacteria infants. Our data highlight important shaping provide solid foundation “personalized” nutrition IMPORTANCE Human broad range carbon sources microbes Levels glycosylation vary may also gestation status mother. This was first study evaluate systematically dynamic statuses 6 months Given unique single nucleotide polymorphism site (rs1047781, A385T) among populations, our report provides specific insight into mothers, exert that differ findings other cohorts.