Effects of statin therapy on the progression of carotid atherosclerosis: a systematic review and meta-analysis.
作者： Sheng Kang , Yangfeng Wu , Xian Li
DOI: 10.1016/J.ATHEROSCLEROSIS.2004.08.005
关键词:
摘要: Observational studies suggested that the progression of carotid atherosclerosis and plaques might be an independent risk factor for coronary artery disease (CAD) stroke, prior researches different dosage statins therapy on in patients had small sample sizes results. We aimed to evaluate efficacy safety rate through randomized controlled trials (RCTs). searched MEDLINE (1980-September 2003), Cochrane Controlled Trials Register, EMBASE (1985-September Science Citation Index PUBMED (updated December 2003). Additional articles were obtained from reference lists relevant reviews papers manual searches. Ten (eight between placebo, two aggressive conventional therapy) included. Two reviewers extracted abstracts, appraised Jadad Score Grading Quality Randomized independently, discrepancies resolved by consensus with a third reviewer. analyzed 10 3443 individuals age range 30 70 years old follow-up 1-4 years. Eight showed rates IMT consistently significantly Z score overall effect was 10.41 (P 0.05). Our findings suggest are efficient safe decrease long-term, may provide superior regression.
elsevier.com
sci-hub.se 参考文章(62)
T. J. Smilde, H. Wollersheim, H. Van Langen, A. F. H. Stalenhoef, Reproducibility of ultrasonographic measurements of different carotid and femoral artery segments in healthy subjects and in patients with increased intima-media thickness. Clinical Science. ,vol. 93, pp. 317- 324 ,(1997) , 10.1042/CS0930317
G D Smith, M J Shipley, G Rose, Intermittent claudication, heart disease risk factors, and mortality. The Whitehall Study. Circulation. ,vol. 82, pp. 1925- 1931 ,(1990) , 10.1161/01.CIR.82.6.1925
Gerald S. Berenson, Wendy A. Wattigney, Richard E. Tracy, William P. Newman, Sathanur R. Srinivasan, Larry S. Webber, Edward R. Dalferes, Jack P. Strong, Atherosclerosis of the aorta and coronary arteries and cardiovascular risk factors in persons aged 6 to 30 years and studied at necropsy (The Bogalusa Heart Study). American Journal of Cardiology. ,vol. 70, pp. 851- 858 ,(1992) , 10.1016/0002-9149(92)90726-F
U. Schminke, L. Hilker, L. Motsch, B. Griewing, C. Kessler, Volumetric assessment of plaque progression with 3-dimensional ultrasonography under statin therapy. Journal of Neuroimaging. ,vol. 12, pp. 245- 251 ,(2002) , 10.1111/J.1552-6569.2002.TB00128.X
Stephen MacMahon, Norman Sharpe, Greg Gamble, Hamish Hart, John Scott, John Simes, Harvey White, Effects of Lowering Average or Below-Average Cholesterol Levels on the Progression of Carotid Atherosclerosis Results of the LIPID Atherosclerosis Substudy Circulation. ,vol. 97, pp. 1784- 1790 ,(1998) , 10.1161/01.CIR.97.18.1784
L. E. Chambless, A. R. Folsom, L. X. Clegg, A. R. Sharrett, E. Shahar, F. J. Nieto, W. D. Rosamond, G. Evans, Carotid Wall Thickness is Predictive of Incident Clinical Stroke: The Atherosclerosis Risk in Communities (ARIC) Study American Journal of Epidemiology. ,vol. 151, pp. 478- 487 ,(2000) , 10.1093/OXFORDJOURNALS.AJE.A010233
Alejandro R. Jadad, R.Andrew Moore, Dawn Carroll, Crispin Jenkinson, D.John M. Reynolds, David J. Gavaghan, Henry J. McQuay, Assessing the quality of reports of randomized clinical trials : is blinding necessary? Controlled Clinical Trials. ,vol. 17, pp. 1- 12 ,(1996) , 10.1016/0197-2456(95)00134-4
A. M. Seifalian, D. P. Mikhailidis, G. Hamilton, I. A. Jagroop, M. Davis, A. S. Atwal, D. R. Nair, The effect of short-term lipid lowering with atorvastatin on carotid artery intima media thickness in patients with peripheral vascular disease: a pilot study. Current Medical Research and Opinion. ,vol. 16, pp. 198- 204 ,(2000) , 10.1185/030079900750119306
I. Jialal, D. Stein, D. Balis, S. M. Grundy, B. Adams-Huet, S. Devaraj, Effect of Hydroxymethyl Glutaryl Coenzyme A Reductase Inhibitor Therapy on High Sensitive C-Reactive Protein Levels Circulation. ,vol. 103, pp. 1933- 1935 ,(2001) , 10.1161/01.CIR.103.15.1933
Frederick J. Raal, Gillian J. Pilcher, Martin G. Veller, Maritha J. Kotze, Barry I. Joffe, Efficacy of vitamin E compared with either simvastatin or atorvastatin in preventing the progression of atherosclerosis in homozygous familial hypercholesterolemia American Journal of Cardiology. ,vol. 84, pp. 1344- 1346 ,(1999) , 10.1016/S0002-9149(99)00570-6