BRAF and NRAS Mutations Are Frequent in Nodular Melanoma but Are not Associated with Tumor Cell Proliferation or Patient Survival

摘要: Previous studies have shown frequent mutations in the BRAF (V-raf murine sarcoma viral oncogene homolog B1) or NRAS (neuroblastoma RAS [V-ras] homolog) genes cutaneous melanoma, but relationship between these alterations and tumor cell proliferation has not been examined human melanoma. In our study of 51 primary nodular melanomas 18 paired metastases, we found (codon 600, previously denoted 599) 15 tumors (29%) eight metastases (44%). The figures for were 27% 22%, respectively. Mutations mutually exclusive all one case, maintained from through their metastases. Mutations, however, associated with by Ki-67 expression, thickness, microvessel density, vascular invasion, there no differences patient survival. Although are likely to be important initiation maintenance some melanomas, other factors might more significant prognosis subgroups aggressive