Vascular actions of 20-HETE.
作者： Samantha L. Hoopes , Victor Garcia , Matthew L. Edin , Michal L. Schwartzman , Darryl C. Zeldin
DOI: 10.1016/J.PROSTAGLANDINS.2015.03.002
关键词:
摘要: 20-hydroxyeicosatetraenoic acid (20-HETE) is a metabolite of arachidonic that exhibits myriad biological effects in the vascular system. This review discusses current knowledge related to 20-HETE on reactivity, activation, and remodeling, as well its role inflammation angiogenesis. The information explaining how renin-angiotensin system interact promote hypertension, vasoconstriction, dysfunction summarized this article. enhances injury models diabetes, ischemia/reperfusion, cerebrovascular oxidative stress. Recent studies also established for normal pathological angiogenesis conditions. will discuss molecular mechanisms through which induces these actions. Potential additional are suggested address shortcomings
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