Canine spontaneous glioma: a translational model system for convection-enhanced delivery.

摘要: Canine spontaneous intracranial tumors bear striking similarities to their human tumor counterparts and have the potential provide a large animal model system for more realistic validation of novel therapies typically developed in small rodent models. We used spontaneously occurring canine gliomas investigate use convection-enhanced delivery (CED) liposomal nanoparticles, containing topoisomerase inhibitor CPT-11. To facilitate visualization intratumoral infusions by real-time magnetic resonance imaging (MRI), we included identically formulated liposomes loaded with Gadoteridol. Real-time MRI defined distribution infusate within both normal brain tissues. The most important limiting factor volume tissue was leakage into ventricular or subarachnoid spaces. Decreased volume, necrosis, modulation phenotype correlated (Vd), infusion location, as determined histopathology. This study demonstrates development therapeutic strategies tumors. Data obtained from monitored real time large, may information, allowing accurate prediction optimization parameters. Variability Vd between strongly suggests that should be an essential component CED trials allow minimization inappropriate assessment clinical outcomes.