Placenta growth factor stimulates MAP kinase and mitogenicity but not phospholipase C-γ and migration of endothelial cells expressing Flt 1

摘要: Vascular endothelial growth factor (VEGF) and placenta (PlGF) are structurally related factors for cells. VEGF binds to the receptor tyrosine kinases Flt 1 KDR/Flk with high affinity, whereas PlGF only 1. Ligand-stimulated KDR is known transduce signals cellular activity such as proliferation migration, weak or no responses have been recorded We examined their capacity stimulate signal transduction in porcine aortic cells expressing KDR. had essentially effect on cells, but induced DNA synthesis migration of other hand not In agreement, MAP kinase, a marker synthesis, was activated both by VEGF-stimulation PlGF-stimulation contrast, phospholipase C-γ (PLC-γ), phosphorylated stimulated PlGF-stimulated which agreement role PLC-γ migration. furthermore induction protein levels plasminogen activator (PA), evident VEGF-stimulated These data show that able mediate an array biological when appropriately pattern distinct from