Inflammation, depressive symptomtology, and coronary artery disease.

摘要: Objective Many patients feel exhausted or depressed before the onset of an acute coronary event, but little is known about origin these feelings. We tested hypothesis that depressive symptomatology associated with a reactivation latent viruses and inflammation vessel. Methods A blood sample was drawn biopsy obtained from lesion 15 nonexhausted treated directional angioplasty because severe angina. Blood samples were analyzed to measure antibody titers against Chlamydia pneumoniae, cytomegalovirus, cytokines interleukin (IL)-1beta, IL-6, tumor necrosis factor (TNF)-alpha. The for presence IL-1beta TNF-alpha. Results Exhausted/depressed had higher levels C. pneumoniae immunoglobulin G, No associations between mental state patient cytokine mRNA in found. Conclusions findings indicate positively serological markers inflammation. It remains be seen whether causes feelings exhaustion, exhaustion depression set stage inflammation, existing are amplified by