Resistance-resistant antibiotics.

摘要: New antibiotics are needed because drug resistance is increasing while the introduction of new decreasing. We discuss here six possible approaches to develop ‘resistance-resistant' antibiotics. First, multitarget inhibitors in which a single compound inhibits more than one target may be easier conventional combination therapies with two drugs. Second, inhibiting multiple targets same metabolic pathway expected an effective strategy owing synergy. Third, discovering multiple-target should by using sequential virtual screening. Fourth, repurposing existing drugs can lead combinations therapeutics. Fifth, need not proteins. Sixth, virulence factor formation and boosting innate immunity also decreased susceptibility resistance. Although it eliminate resistance, reviewed offer several possibilities for reducing effects mutations and, some cases, suggest that sensitivity restored otherwise drug-resistant organisms.