The Effect of Iranian Propolis on Glucose Metabolism, Lipid Profile, Insulin Resistance, Renal Function and Inflammatory Biomarkers in Patients with Type 2 Diabetes Mellitus: A Randomized Double-Blind Clinical Trial

摘要: Propolis is a natural product with many biological properties including hypoglycemic activity and modulating lipid profile. The present study was designed to evaluate the effect of Iranian propolis extract on glucose metabolism, Lipid profile, Insulin resistance, renal liver function as well inflammatory biomarkers in patients type 2 diabetes mellitus (T2DM). A double-blind, placebo-controlled clinical trial conducted. duration lasted 90 days. Patients T2DM were recruited randomly divided into an group (1000 mg/day) (n = 50) placebo (n = 44). There significant decrease serum levels glycosylated hemoglobin (HbA1c), 2-hour post prandial (2hpp), insulin, homeostasis model assessment-insulin resistance (HOMA-IR), assessment β-cell (HOMA-β), High sensitive C-reactive protein (hs-CRP), tumor necrosis factor-α (TNF-α). However, there notable elevation HDL-C compared group. In addition, reduction transaminase (ALT AST) blood urea nitrogen (BUN) concentrations observed. has beneficial effects reducing glucose, insulin cytokines. It also useful treatment for preventing dysfunction, as, elevating T2DM.