Myeloid Cells in the Tumor Microenvironment: Modulation of Tumor Angiogenesis and Tumor Inflammation
作者： Michael C. Schmid , Judith A. Varner
DOI: 10.1155/2010/201026
关键词:
摘要: Myeloid cells are a heterogeneous population of bone marrow-derived that play critical role during growth and metastasis malignant tumors. Tumors exhibit significant myeloid cell infiltrates, which actively recruited to the tumor microenvironment. promote by stimulating angiogenesis, suppressing immunity, promoting distinct sites. In this review, we discuss in angiogenesis. Furthermore, describe subset with immunosuppressive activity (known as myeloid-derived suppressor cells). Finally, will comment on mechanisms regulating recruitment microenvironment potential new targets for cancer therapy.
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