Cholera Vaccine Use Is Associated With a Reduced Risk of Death in Patients With Colorectal Cancer: A Population-Based Study.

摘要: Background & Aims Cholera toxin can act as a modulator of the immune response with anti-inflammatory effects; it reduces development colon polyps in mouse models colorectal cancer (CRC). We performed population-based study to determine whether, patients diagnosis CRC, subsequent administration cholera vaccine (killed Vibrio cholerae O1 whole cells and recombinant B subunit) affects mortality. Methods identified from Swedish Cancer Register who were diagnosed CRC July 2005 through December 2012. These linked Prescribed Drug to retrieve use. used Cox regression analysis calculate hazard ratio (HR) death overall mortality post-diagnostic use compared matched controls. Results A total 175 given prescription for after their diagnosis. Compared propensity score-matched controls adjusted confounding factors, who received had decreased risk (HR, 0.53; 95% CI, 0.29–0.99) 0.59; 0.37–0.94). The decrease vaccination was largely observed, irrespective patient age or tumor stage at sex. Conclusions In study, we associated with decreased