High-sensitivity cardiac troponin T for detection of subtle abnormalities of cardiac phenotype in a general population of elderly individuals.

摘要: Objective To investigate the association between circulating cardiac biomarkers and minor abnormalities in phenotype [left ventricular (LV) mass midwall fractional shortening (MFS)] elderly individuals a general population sample. Design setting We examined relationship plasma concentrations of high-sensitivity troponin T (hs-cTnT) or N-terminal probrain natriuretic peptide (NT-proBNP) elevated LV (LV mass/body surface area >95 g m−2 for women 115 g m−2 men), reduced MFS (<15%) isolated diastolic dysfunction 1973 subjects (mean age 73 ± 5 years, range 65–84) resident Lazio region Italy enrolled PREDICTOR study. Results Overall, 24.8% had mass, 30.4% MFS. Median [quartile 1–3] hs-cTnT NT-proBNP were higher with than those normal mass: 6.6 [3.5–11.6] 147 [64–296] ng L−1 vs. 4.6 [3.0–8.1] 79 [41–151] respectively (P < 0.001). There was graded increase median across clinical categories hypertrophy: [3.0–8.1], 5.8 [3.1–10.2], 7.6 [3.8–13.7] 8.4 [3.8–17.6] mild, moderate severe hypertrophy (P < 0.0001); also increased increasing quartiles grades dysfunction. Conclusions Within an extremely low concentrations, amongst community-dwelling is associated subtle alterations phenotype, suggesting that injury to myocytes subsequent release reflect subclinical pathophysiological deterioration this population.