Chemical and Pathway Proteomics Powerful Tools for Oncology Drug Discovery and Personalized Health Care

摘要: In recent years mass spectrometry-based proteomics has moved beyond a mere quantitative description of protein expression levels and their possible correlation with disease or drug action. Impressive progress in LC-MS instrumentation together the availability new enabling tools methods for proteome analysis identification posttranslational modifications triggered surge chemical functional studies dissecting mechanisms action cancer drugs molecular that modulate signal transduction pathways. Despite tremendous been made field, major challenges, relating to sensitivity, dynamic range, throughput described methods, remain. this review we summarize advances LC-MS-based approaches application discovery cancer-related pathways cell culture models particular emphasis on mechanistic these systems. Moreover highlight emerging utility pathway techniques translational research patient tissue.