The Immune Response to Class I-Associated Tumor-Specific Cutaneous T-Cell Lymphoma Antigens

摘要: In order to determine whether the neoplastic T cells from patients with cutaneous T-cell lymphoma express tumor-specific antigens that can serve as targets of an immune response, we took advantage family-specific monoclonal antibodies, magnetic bead technology, and recombinant cytokines, which provided previously precluded ability isolate expand populations purified tumor autologous CD8 cytotoxic cells. Four advanced had specifically killed in a class I limited fashion. Tumor cell cytolysis could be enhanced by pre-culture γ -irradiated tumor. The cytolytic produced necrosis factor- α response stimulation presence recognizing distinctive associated molecules on suggests infiltration early lesions reflects host immunity neoplasm. These studies provide foundation for development vaccines through use characterize tumor-associated peptides.