Strontium-containing mesoporous bioactive glass scaffolds with improved osteogenic/cementogenic differentiation of periodontal ligament cells for periodontal tissue engineering
作者： Chengtie Wu , Yinghong Zhou , Chucheng Lin , Jiang Chang , Yin Xiao
DOI: 10.1016/J.ACTBIO.2012.06.023
关键词:
摘要: To achieve the ultimate goal of periodontal tissue engineering, it is great importance to develop bioactive scaffolds which could stimulate osteogenic/cementogenic differentiation ligament cells (PDLCs) for favorable regeneration alveolar bone, root cementum, and ligament. Strontium (Sr) Sr-containing biomaterials have been found induce osteoblast activity. However, there no systematic report about interaction between Sr or PDLCs engineering. The aims this study were prepare mesoporous glass (Sr-MBG) investigate whether addition in engineering scaffold system. composition, microstructure mesopore properties (specific surface area, nano-pore volume distribution) Sr-MBG characterized. proliferation, alkaline phosphatase (ALP) activity osteogenesis/cementogenesis-related gene expression (ALP, Runx2, Col I, OPN CEMP1) on different kinds systematically investigated. results show that plays an important role influencing structure MBG high contents decreased well-ordered mesopores as well their area/pore volume. Sr2+ ions be released from a controlled way. incorporation into has significantly stimulated ALP PDLCs. Furthermore, simulated body fluids environment still maintained excellent apatite-mineralization ability. suggests viable way biological response are promising material application.
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