Activated T cells and eosinophilia in bronchoalveolar lavages from subjects with asthma correlated with disease severity
作者： Christoph Walker , Martin K. Kaegi , Peter Braun , Kurt Blaser
DOI: 10.1016/0091-6749(91)90251-I
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摘要: Abstract Activated T-lymphocytes may regulate the eosinophilic inflammation of bronchial asthma. In present study, we investigated T cell activation and eosinophilia in blood bronchoalveolar lavage (BAL) 17 patients with asthma not receiving steroid treatment. Compared to normal individuals, BAL from contained significantly increased numbers both lymphocytes eosinophils (EOSs). The lymphocytosis consisted CD4 + CD8 cells, these populations expressed elevated levels markers (interleukin-2 receptor [CD25], HLA-DR, very late antigen 1). Close correlation was found between 1L-2R cells EOSs. Moreover, activated EOSs were related severity as measured by impairment FEV 1 methacholine responsiveness. We demonstrate a close activation, eosinophilia, asthma, suggesting that recruitment are fundamental pathogenesis
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