Identity of HeLa cell determinants acquired by vesicular stomatitis virus with a tumor antigen

作者: L. Little , J Zavada , C. Der , A. Huang

DOI: 10.1126/SCIENCE.6302845

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摘要: Growth of vesicular stomatitis virus (VSV) in HeLa cells results progeny containing non-VSV antigens with a molecular weight around 75,000. The were detected by antiserums to cell determinants. These precipitate whole virions but do not neutralize them. Because one the is directed tumor-specific surface antigen cells, it appears that VSV specifically acquires such during its passage through human tumor cells.

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