Polysomnographic Correlates for the Risk of Relapse in Detoxified Opiate-Misuse Patients.

摘要: Introduction Substance abuse is a complex issue requiring multi-disciplinary management. Protracted abstinence syndrome leads to persistent discomfort even after detoxification lasting months, resulting in poor sleep duration and quality. Despite being major contributor relapse disturbances, no objective assessment procedures monitor the have been reported. The study aims assess structure via polysomnography psychometrically over next 6 months abstinent relapsing patients. Methods Sixty successfully detoxified males (35.8 ± 7.3 years) with history of heroin (DSM-V) (mean composite scores (ASI): 1.3 0.06, 3.48 0.38, 5.45 0.63, 1.2 0.19, 3.93 0.9, 2.61 0.8 for medical status, employment/support alcohol/drugs legal family/social relationships, psychiatric respectively) were recruited immediately following their detoxification, without giving additional psychoactive substances or medications. Polysomnography was done second week allow washout medications, followed by monthly through diary daytime sleepiness using visual analog scale. Relapse proved urine test. Polysomnographic parameters ASI subscales non-relapsing participants compared 2-tailed Student's t-test (p<0.05). Results Eighteen relapsed (12 3 months). Only problems score significantly different two groups (p=0.001). differences significant NREM stages I (p=0.001) II (p=0.002), bilateral limb movement (p=0.009), arousal indices Conclusion Measuring polysomnographic (percentage II, index, index) disturbance heroin-abuse patients can be potential predictors 6-month follow-up.