Resistance to multiple chemotherapeutic agents in human cancer cells.
作者： Michael M. Gottesman , Ira Pastan
DOI: 10.1016/0165-6147(88)90117-4
关键词:
摘要: Abstract Human cancer cells selected for resistance to multiple Hydrophobie cytotoxic drugs express the cell surface P-glycoprotein, which is product of MDR1 gene. In this review Michael Gottesman and Ira Pastan discuss genetic biochemical data indicating that P-glycoprotein a major component an energy-dependent efflux system antagonized by specific agents prevent binding protein. Expression occurs in normal liver, kidney, colon, jejunum adrenal gland, suggesting protein functions as transport compounds. Many multidrug-resistant tumors arising from these tissues elevated levels, do some become drug-resistant during chemotherapy.
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