Chapter 13. New Approaches to Antitumor Therapy

摘要: Publisher Summary This chapter discusses the three representative new approaches to anti-tumor therapy: circumvention of multidrug resistance, antagonism mitogenic growth factors, and finally inhibition oncogenic tyrosine kinases. Multidrug resistance (MDR) is characterized by cross-resistance a group structurally mechanistically distinct antitumor agents. MDR can be induced expression human mdr1 cDNA also gene transfection. Expression occurs in normal tissues, such as colon, lung, liver, kidney, that are frequently exposed xenobiotics. Thus, or reversal phenotype appears promising clinical target for improvement current therapy. In addition calcium antagonists, diverse range pharmacologically drugs have been shown reverse MDR. Growth factor involvement maintenance transformed likely heterogeneous at tumor level. The protein kinases, appear play important roles transduction signals initiating cellular replication transformation, represent one type an ever-increasing family regulatory Protein kinases now associated with several cancers. plethora makes development inhibitor specific particular formidable task. Selective possible result selective inhibition. As pharmacologic agents emerge from these areas, their value therapies only judged trials.