Mechanism of WASP and WAVE family proteins in the progression of prostate cancer.

摘要: Prostate cancer (PCa) is the second most commonly diagnosed and third lethal cause of death from in men worldwide. Despite availability vast treatment procedures, still high occurrence invasion metastasis PCa are reported patients. The WASP (Wiskott-Aldrich syndrome protein) WAVE (WASP family verprolin homologous proteins actin cytoskeleton regulatory proteins, to enhance cell migration prostate cancer. Hence, this review sheds light on studies that explored potential role research articles for completion were mostly PubMed Google Scholar by using appropriate keywords indexing. conserved function protein receive upstream signals Rho GTPase transmit them activate Arp2/3 complex leads rapid polymerization at leading edge cells, which crucial metastasis. Therefore, targeting these could reflect a very interesting therapeutic opportunity combat