Loss of Wave1 gene defines a subtype of lethal prostate cancer
作者： Adam G. Sowalsky , Rebecca Sager , Rachel J. Schaefer , Gennady Bratslavsky , Pier Paolo Pandolfi
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摘要: Genetic alterations involving TMPRSS2-ERG and deletion of key tumor suppressor genes are associated with development progression prostate cancer (PCa). However, less defined early events that may contribute to the high-risk metastatic cancer. Bioinformatic analysis existing genomic data from PCa patients revealed WAVE complex gene a greater likelihood recurrence. Further primary vs. castration resistant indicate disruption expression, particularly WAVE1 (WASF1) loss, is also resistance, where WASF1 frequently co-deleted PTEN resists androgen deprivation therapy (ADT). Hence, we propose status defines subtype ADT-resistant patients. Better understanding effects pathway will lead better diagnostic treatment modalities.
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