Mycotoxins-Induced Oxidative Stress and Disease

摘要: Mycotoxins are pharmacologically active mold metabolites produced in a strain-specific way that elicit some complicated toxicological activities [1]. More than 300 secondary have been identified while only around 30 true toxic properties [2]. The chemical structures of mycotoxins vary significantly, but they low molecular mass organic compounds [3]. small and quite stable molecules which extremely difficult to remove enter the food feed chain keeping their [4]. So, occurrence is regulated by legal limits all developed countries [5]. Mycotoxin contamination global problem because more 25% world grain production contaminated [6]. synthesis moulds genetically determined closely related primary metabolic pathways, such as amino acid fatty metabolism. However, actual toxin modulated environmental factors substrate composition quality, humidity temperature. animal exhibits geographic pattern, for example Aspergillus species meet optimal conditions tropical subtropical regions, whereas Fusarium Penicillium adapted moderate climate. Worldwide trade with commodities results wide distribution material [7].