Preparation of sulfhydrylborane-dextran conjugates for boron neutron capture therapy
作者： Anders Holmberg , Lennart Meurling
DOI: 10.1021/BC00024A023
关键词:
摘要: This study presents a carrier system for boron, potentially useful in boron neutron capture therapy (BNCT). Na2B12H11SH (BSH) was covalently coupled to dextran derivatives. accomplished two ways. The first method comprises activation of with 1-cyano-4-(dimethylamino)pyridine (CDAP) subsequent coupling 2-aminoethyl pyridyl disulfide (method A). thiolated could then couple BSH exchange reaction. In the second procedure, derivatized multially derivative B) which reacted free-radical-initiated addition assessment content conjugates done by elemental analysis sulfur and atomic spectroscopy (ICP-AES). With A, only limited numbers cages be (10-20 per chain). B, 100-125 chain obtained, corresponding 1200-1500 atoms chain. result makes this promising template use development BNCT agents.
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