The P2X7 Receptor Channel: Recent Developments and the Use of P2X7 Antagonists in Models of Disease
作者： Rachael Bartlett , Leanne Stokes , Ronald Sluyter
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摘要: The P2X7 receptor is a trimeric ATP-gated cation channel found predominantly, but not exclusively, on immune cells. activation results in number of downstream events, including the release proinflammatory mediators and cell death proliferation. As such, plays important roles various inflammatory, immune, neurologic musculoskeletal disorders. This review focuses use antagonists rodent models disease injury, inflammation, other cloning characterization human, rat, mouse, guinea pig, dog, Rhesus macaque P2X7, as well recent observations regarding gating permeability are discussed. Furthermore, this discusses polymorphic splice variants generation knockout mice. Recent evidence for emerging signaling pathways growing list negative positive modulators expression also described. In addition, numerous extensively summarized. Finally, clinical trials humans future directions exploring therapeutic target
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