Role of Cellular and Viral Proteases in the Processing of Picornavirus Proteins

摘要: The replication of picornaviruses requires the action proteolytic enzymes on viral precursor proteins. protein cleavages are often crucial to virus process, so that a complete understanding their role could lead development new types antiviral agents. On more fundamental level, characterization reactions in infections is leading fuller appreciation regulation function by limited proteolysis. picornavirus model which modifications yield macromolecular complexes with altered conformational and antigenic properties, affinities for nucleic acids receptors cell membranes. Obviously, there general significance these phenomena similar events cellular interactions numerous occurring tissues fluids higher organisms. For recent reviews cleavage replication, see ref. 1–3.