Novel chemotherapeutic agents for the treatment of brain cancer

摘要: Brain cancer encompasses both primary and metastatic brain tumours accounts for over 120,000 new patients each year. Despite aggressive therapy, the majority of with have poor prognosis brief survival intervals. Current chemotherapy drugs, used alone or in combination, minimal only modest activity. Novel agents that recently been applied to include temozolomide, irinotecan paclitaxel. Temozolomide is a DNA alkylating agent, inhibits topoisomerase I paclitaxel binds microtubules induces polymerisation. Neoplastic angiogenesis tumour invasion are also targets therapeutic intervention such as thalidomide, suramin marimastat. All these demonstrated activity against vitro. Several particular irinotecan, entered preliminary clinical trials some efficacy. However, primar...