Cellular and molecular mechanisms of pentoxifylline's beneficial effects in experimental polycystic ovary

摘要: Abstract Chronic low-grade inflammation and oxidative stress (OS) appear to be two main pathways involved in the pathogenesis of polycystic ovary (PCO) syndrome. Therefore, targeting these by means anticytokine antioxidant agents might a therapeutic alternative approach current treatments PCO In this study, we investigated protective effects pentoxifylline (PTX), drug with anti–tumor necrosis factor alpha (TNF-α) properties, hyperandrogenism-induced rats. The inflammatory OS responses their connections ovarian functionality induced rats were through histopathologic examination series biochemical measurements including serum estradiol, progesterone, testosterone, insulin, TNF-α, lipid peroxidation, total power, reactive oxygen species. Experimental was oral administration letrozole (1 mg/kg body weight) for 21 consecutive days. different group, PTX administrated orally (50 mg/kg/d) 21 days simultaneous assess its potential effects. letrozole-induced PCOs characterized irregular cycles, high incidence subcapsular cysts diminished or scant granulosa cell layers, increased number atretic preantral antral follicles, absence CL. addition, exhibited notable increase peroxidation species ovary, TNF-α significant decline progesterone. Our results indicated that all identified pathologic parameters characteristics study preserved close normal levels treatments. Present demonstrate there is direct connection between dysfunction PCO. For first time, beneficial as powerful blocker are reported.