Investigation of the properties of novel acrylamido monomers by capillary zone electrophoresis

摘要: Abstract A series of mono- and disubstituted acrylamide monomers [monomethylacrylamide, dimethylacrylamide, trisacryl (Tris-A), dideoxy- acryloylmorpholine] were investigated as potential candidates a novel class polyacrylamide matrices, exhibiting high hydrophilicity, resistance to hydrolysis larger pore size than conventional gels. However, the most promising monomer (Tris-A) exhibited first-order degradation kinetics in 0.1 M NaOH, suggesting that such structure is electronically unstable. On other hand, fact that, once incorporated into polymer chain, strong alkaline suggests perhaps, poly(trisacryl) matrix could be stereoregular, perhaps via helix formation. Another unique finding inverse relationship between partition coefficient incorporation efficiency: more hydrophobic members family exhibit very poor conversion from polymer. The efficiency, however, can dramatically increased by increasing polymerization temperature 25 60°C.