Establishment of a new Epstein-Barr virus-immortalized cell line from chronic lymphocytic leukemia with trisomy of chromosome 12 that produces monoclonal IgM against a sheep RBC antigen.

作者: M Crescenzi , M Napolitano , M Carbonari , A Antonelli , P Petrinelli

DOI: 10.1182/BLOOD.V71.1.9.9

关键词:

摘要: Leukemia cells from a patient with chronic lymphocytic leukemia (CLL) were found to bind sheep RBC (SRBC) through their monoclonal surface IgM. A lymphoblastoid cell line was obtained by immortalization of leukemic Epstein-Barr virus (EBV). Cultured have supernumerary chromosome 12, an abnormality typical CLL the B type. To our knowledge, this is first EBV-immortalized B-CLL known SRBC specificity and third reported carrying trisomy 12.

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