Ketorolac prevents postoperative small intestinal ileus in rats

作者: Mark C. Kelley , Michael P. Hocking , Susan D. Marchand , Charles A. Sninsky

DOI: 10.1016/S0002-9610(05)80412-X

关键词:

摘要: The effect of ketorolac, a parenterally administered, nonsteroidal anti-inflammatory drug, was examined in rat model postoperative ileus. Small intestinal transit measured by calculating the geometric center (GC) distribution 51 CrO 4 . Laparotomy significantly delayed (GC: 2.2 ±0.2 after laparotomy versus 5.6±0.5 for unoperated controls, p

参考文章(24)
Gary M. Levine, Julius J. Deren, Ezra Steiger, Ronald Zinno, Role of oral intake in maintenance of gut mass and disaccharide activity. Gastroenterology. ,vol. 67, pp. 975- 982 ,(1974) , 10.1016/S0016-5085(19)32752-0
Furness Jb, Costa M, Adynamic ileus, its pathogenesis and treatment Medical biology. ,vol. 52, pp. 82- 89 ,(1974)
Regal Me, Lichtig L, Moss G, Reducing postoperative pain, narcotics, and length of hospitalization. Surgery. ,vol. 99, pp. 206- 210 ,(1986)
WALTER B. CANNON, FRED T. MURPHY, IV. The Movements of the Stomach and Intestines in Some Surgical Conditions. Annals of Surgery. ,vol. 43, pp. 512- 536 ,(1906) , 10.1097/00000658-190604000-00004
Mary J. Ruwart, Michael S. Klepper, Bobby D. Rush, Carbachol stimulation of gastrointestinal transit in the postoperative lleus rat Journal of Surgical Research. ,vol. 26, pp. 18- 26 ,(1979) , 10.1016/0022-4804(79)90073-8
Matthew S. Miller, James J. Galligan, Thomas F. Burks, Accurate measurement of intestinal transit in the rat Journal of Pharmacological Methods. ,vol. 6, pp. 211- 217 ,(1981) , 10.1016/0160-5402(81)90110-8
Lionel Bueno, Jean-Pierre Ferre, Yves Ruckebusch, Effects of anesthesia and surgical procedures on intestinal myoelectric activity in rats. Digestive Diseases and Sciences. ,vol. 23, pp. 690- 695 ,(1978) , 10.1007/BF01072353
Jacques Smith, Pathophysiology of Postoperative Ileus Archives of Surgery. ,vol. 112, pp. 203- 209 ,(1977) , 10.1001/ARCHSURG.1977.01370020097011