Long-term survival after liver metastasectomy in gastric cancer: Systematic review and meta-analysis of prognostic factors.

摘要: Abstract Background Despite the amelioration of systemic therapy, overall survival (OS) metastatic gastric cancer (GC) patients remains poor. Liver is a common site and retrospective series suggest potential OS benefit from hepatectomy, with interesting 5-year (5 y) 10-year (10 y) rates in selected patients. We aim to evaluate impact liver resection related prognostic factors on long-term outcome this setting. Methods searched Pubmed, EMBASE, Abstracts/posters international meetings since 1990. Data were extracted publish papers. Random effects models meta-analyses meta-regression built assess 5yOS different factor. Heterogeneity was assessed using between study variance, I2 Cochran’s Q. Funnel plot used small bias. Results Thirty-three observational studies (for total 1304 patients) included. Our analysis demonstrates rate 22% (95%CI: 18–26%) 10yOS 11% 7–18%) among undergoing radical hepatectomy. A favorable effect shown by several linked primary (lower T N stage, no lympho-vascular or serosal invasion) burden hepatic disease (≤3 metastases, unilobar involvement, greatest lesion  Conclusions Surgical metastases GC seems associated significant chance compares favourably results medical treatment alone. Prospective evaluation approach validation adequate selection criteria are needed.