Cytogenetic studies of human testicular germ cell tumours
作者： CELIA D. DELOZIER-BLANCHET , H. WALT , E. ENGEL , P. VUAGNAT
DOI: 10.1111/J.1365-2605.1987.TB00167.X
关键词:
摘要: In a search for consistent cytogenetic alterations in testicular germ cell cancers we have thus far studied some twenty surgical specimens of seminomas and nonseminomatous tumours. From the literature our results it is now clear that such tumours generally hyperdiploid to hypotriploid chromosomal content, frequently possess possibly site-specific marker, an isochromosome 12p. A significant correlation between presence i(12p) advanced clinical stages has been revealed study. Several other regions are consistently involved changes: 1p 1q, 6q, 7p, 9q, 12p, 17q, 22q. Although there little doubt characteristic lesions exist tumours, impact which specific may on tumour progression still unclear.
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