A Five-Amino-Acid Peptide Blocks Met- and Ron-Dependent Cell Migration
作者： Alexandra Matzke , Peter Herrlich , Helmut Ponta , Véronique Orian-Rousseau
DOI: 10.1158/0008-5472.CAN-05-0207
关键词:
摘要: Various human cancers express elevated levels of the receptor tyrosine kinases Met or Ron and v6-containing isoforms CD44. The activation requires presence such CD44 that act as coreceptors. Three amino acids within v6 sequence were identified by mutational analysis to be essential for coreceptor function: EWQ in rat RWH human. Peptides comprising these three (the smallest containing only five acids) efficiently competitors block ligand-dependent subsequent cell migration.
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