Angiogenesis as an unfavorable prognostic factor in human colorectal carcinoma
作者： Yuji Takebayashi , Shin-ichi Akiyama , Kazutaka Yamada , Suminori Akiba , Takashi Aikou
DOI: 10.1002/(SICI)1097-0142(19960715)78:2<226::AID-CNCR6>3.0.CO;2-J
关键词:
摘要: BACKGROUND Angiogenesis is reportedly correlated with metastasis, relapse, and prognosis in some types of tumors. Hematogenous or lymph node metastasis local recurrence are the main elements related to death patients colorectal carcinoma. Thus, authors examined microvessel count carcinoma determine how angiogenesis correlates clinicopathologic factors prognosis. METHODS Paraffin embedded sections from 166 primary carcinomas that had been completely removed were analyzed for angiogenesis. Vessels stained anti-factor VIII polyclonal antibody, areas most discrete microvessels counted a 400× field. RESULTS Tumor size was significantly count. Microvessel counts lymphatic vessel invasion, venous relapse higher than those without. Furthermore, an independent prognostic factor (P = 0.007), whereas Dukes stage more significant value < 0.001) according multivariate Cox hazard analysis. CONCLUSIONS This study suggested assessed by marker Cancer 1996;78:226-31.
sci-hub.se 参考文章(32)
Su-ming Hsu, Laurence Raine, Herbert Fanger, A comparative study of the peroxidase-antiperoxidase method and an avidin-biotin complex method for studying polypeptide hormones with radioimmunoassay antibodies. American Journal of Clinical Pathology. ,vol. 75, pp. 734- 738 ,(1981) , 10.1093/AJCP/75.5.734
K. Horgan, Anurag Srivastava, P. Laidler, R. P. Davies, L. E. Hughes, The prognostic significance of tumor vascularity in intermediate-thickness (0.76-4.0 mm thick) skin melanoma. A quantitative histologic study. American Journal of Pathology. ,vol. 133, pp. 419- 423 ,(1988)
P R Carroll, N Weidner, J Flax, W Blumenfeld, J Folkman, Tumor angiogenesis correlates with metastasis in invasive prostate carcinoma. American Journal of Pathology. ,vol. 143, pp. 401- 409 ,(1993)
David E. Burstein, Daniel B. Rifkin, David Zagzag, Douglas C. Miller, Yasufumi Sato, Immunohistochemical Localization of Basic Fibroblast Growth Factor in Astrocytomas Cancer Research. ,vol. 50, pp. 7393- 7398 ,(1990)
David R. Cox, Regression Models and Life-Tables Springer Series in Statistics. ,vol. 34, pp. 527- 541 ,(1992) , 10.1007/978-1-4612-4380-9_37
Michael A. Gimbrone, Ramzi S. Cotran, Stephen B. Leapman, Judah Folkman, Tumor Growth and Neovascularization: An Experimental Model Using the Rabbit Cornea Journal of the National Cancer Institute. ,vol. 52, pp. 413- 427 ,(1974) , 10.1093/JNCI/52.2.413
Stephen B. Fox, Russell D Leek, Kenneth Smith, Justine Hollyer, Michael Greenall, Adrian L. Harris, Tumor angiogenesis in node-negative breast carcinomas--relationship with epidermal growth factor receptor, estrogen receptor, and survival. Breast Cancer Research and Treatment. ,vol. 29, pp. 109- 116 ,(1994) , 10.1007/BF00666186
E. L. Kaplan, Paul Meier, Nonparametric Estimation from Incomplete Observations Springer Series in Statistics. ,vol. 53, pp. 319- 337 ,(1992) , 10.1007/978-1-4612-4380-9_25
Judah Folkman, Karol Watson, Donald Ingber, Douglas Hanahan, Induction of angiogenesis during the transition from hyperplasia to neoplasia Nature. ,vol. 339, pp. 58- 61 ,(1989) , 10.1038/339058A0
Yuji Takebayashi, Kazutaka Yamada, Ikuro Maruyama, Ryu-ichi Fujii, Shin-ichi Akiyama, Takashi Aikou, The expression of thymidine phosphorylase and thrombomodulin in human colorectal carcinomas. Cancer Letters. ,vol. 92, pp. 1- 7 ,(1995) , 10.1016/0304-3835(94)03754-7