Epidermal growth factor receptor in non-small-cell lung carcinomas: correlation between gene copy number and protein expression and impact on prognosis.
作者： Fred R. Hirsch , Marileila Varella-Garcia , Paul A. Bunn , Michael V. Di Maria , Robert Veve
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摘要: Purpose: The epidermal growth factor receptor (EGFR) is frequently overexpressed in non–small-cell lung carcinoma (NSCLC), and EGFR inhibitors are promising new therapeutic agents. molecular mechanisms responsible for overexpression poorly understood. Materials Methods: Gene copy number protein status of were investigated microarrayed tumors from 183 NSCLC patients, including squamous cell (SCC; 89 patients) non-SCC (94 histologies. Protein expression was assessed by immunohistochemistry on a scale 0 to 400 (percentage positive cells × staining intensity). chromosome 7 numbers identified fluorescent situ hybridization (FISH). Results: observed 62% the (25% scored 201 300; 37% 301 400), more SCC than (82% v 44%; P < .001), 80% bronchioloalveolar carcinomas. prevalent FISH patterns balanced disomy (40%) trisomy (38%) f...
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