HIV suppression by host restriction factors and viral immune evasion
作者： Xiaofei Jia , Qi Zhao , Yong Xiong
DOI: 10.1016/J.SBI.2015.04.004
关键词:
摘要: Antiviral restriction factors are an integral part of the host innate immune system that protects cells from viral pathogens, such as human immunodeficiency virus (HIV). Studies interactions between and HIV have greatly advanced our understanding both life cycle basic cell biology, well provided new opportunities for therapeutic intervention infection. Here we review recent developments towards establishing structural biochemical bases inhibition by, countermeasures of, TRIM5, MxB, APOBEC3, SAMHD1, BST2/tetherin.
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