Focal adhesion kinase knockdown in carcinoma-associated fibroblasts inhibits oral squamous cell carcinoma metastasis via downregulating MCP-1/CCL2 expression.
作者： Anjie Min , Chao Zhu , Jingyi Wang , Shuping Peng , Cijun Shuai
DOI: 10.1002/JBT.21669
关键词:
摘要: Carcinoma-associated fibroblasts (CAFs) have been demonstrated to play an important role in the occurrence and development of oral squamous cell carcinoma (OSCC). The aim this study is investigate influence CAFs on OSCC cells explore focal adhesion kinase (FAK) process. results showed that expressed a higher level FAK than normal human gingival (HGFs), conditioned medium (CM) could induce invasion migration SCC-25, one line. However, knockdown by small interfering RNA (siRNA) resulted inhibition CAF-CM induced probably reducing production monocyte chemoattractant protein-1 (MCP-1/CCL2), downstream target chemokines. Therefore, our findings indicated targeting might be promising strategy for treatment future.
sci-hub.se 参考文章(24)
Shuo-Hsiu Hsu, Yong-Kie Wong, Ching-Ping Wang, Chen-Chi Wang, Rong-San Jiang, Fun-Jou Chen, Shih-An Liu, Survival analysis of patients with oral squamous cell carcinoma with simultaneous second primary tumors Head and Neck-journal for The Sciences and Specialties of The Head and Neck. ,vol. 35, pp. 1801- 1807 ,(2013) , 10.1002/HED.23242
John M. Walker, Basic protein and peptide protocols : Humana Press. ,(1994) , 10.1385/089603268X
L. Gu, S.C. Tseng, B.J. Rollins, Monocyte Chemoattractant Protein-1 Chemical Immunology and Allergy. ,vol. 72, pp. 7- 29 ,(1999) , 10.1159/000058723
Lance A. Liotta, Elise C. Kohn, The microenvironment of the tumour-host interface Nature. ,vol. 411, pp. 375- 379 ,(2001) , 10.1038/35077241
Janet Dawson, Wolfgang Miltz, Anis K Mir, Christoph Wiessner, Targeting monocyte chemoattractant protein-1 signalling in disease Expert Opinion on Therapeutic Targets. ,vol. 7, pp. 35- 48 ,(2003) , 10.1517/14728222.7.1.35
Paolo Cirri, Paola Chiarugi, Cancer-associated-fibroblasts and tumour cells: a diabolic liaison driving cancer progression Cancer and Metastasis Reviews. ,vol. 31, pp. 195- 208 ,(2012) , 10.1007/S10555-011-9340-X
Liang Ding, Bing Li, Ying Zhao, Yi-Fu Fu, Er-Ling Hu, Qin-Gang Hu, Yan-Hong Ni, Ya-Yi Hou, Serum CCL2 and CCL3 as potential biomarkers for the diagnosis of oral squamous cell carcinoma Tumor Biology. ,vol. 35, pp. 10539- 10546 ,(2014) , 10.1007/S13277-014-2306-1
Alexander Berndt, Robert Büttner, Stefanie Gühne, Anna Gleinig, Petra Richter, Yuan Chen, Marcus Franz, Claus Liebmann, Effects of activated fibroblasts on phenotype modulation, EGFR signalling and cell cycle regulation in OSCC cells. Experimental Cell Research. ,vol. 322, pp. 402- 414 ,(2014) , 10.1016/J.YEXCR.2013.12.024
Maria Letizia Taddei, Elisa Giannoni, Giuseppina Comito, Paola Chiarugi, Microenvironment and tumor cell plasticity: An easy way out. Cancer Letters. ,vol. 341, pp. 80- 96 ,(2013) , 10.1016/J.CANLET.2013.01.042
Britta Dreier, Vijaya krishna Raghunathan, Paul Russell, Christopher J. Murphy, Focal adhesion kinase knockdown modulates the response of human corneal epithelial cells to topographic cues. Acta Biomaterialia. ,vol. 8, pp. 4285- 4294 ,(2012) , 10.1016/J.ACTBIO.2012.07.004