Stress Induces AMP-Dependent Loss of Potency Factors Id2 and Cdx2 in Early Embryos and Stem Cells
作者： Yufen Xie , Awoniyi Awonuga , Jian Liu , Edmond Rings , Elizabeth Ella Puscheck
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摘要: The AMP-activated protein kinase (AMPK) mediates rapid, stress-induced loss of the inhibitor differentiation (Id)2 in blastocysts and trophoblast stem cells (TSC), a lasting TSC. However, it is not known if AMPK regulates other potency factors or them before blastocyst stage. caudal-related homeodomain (Cdx)2 regulatory gene for determining TSC, earliest placental lineage preimplantation mouse embryo, but expressed oocyte early cleavage stage embryos TSC arise. We assayed expression putative potency-maintaining phosphorylated Cdx2 ser60 oocyte, two-cell blastocyst, studied phospho induced by hyperosmolar stress its underlying mechanisms. Hyperosmolar caused rapid nuclear Id2 embryo 0.5 h. Stress-induced reversed compo...
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