Comparative and veterinary pharmacogenomics

摘要: Pharmacogenomics is the study of impact genetic variation on drug effects, with ultimate goal achieving “personalised medicine”. Since completion Human Genome Project, great strides have been made towards personalised dosing drugs in people, as exemplified by development gene-guided anticoagulant drug, warfarin. Although pharmacogenomics domestic animals still at an early stage development, there potential for advances coming years direct result complete genome sequences currently being derived many species significance to veterinary and comparative medicine. This sequence information used discover variants candidate genes associated altered response, well develop whole high density single nucleotide polymorphism arrays genotype–phenotype linkage analysis. review summarises current state research, including response variability phenotypes either known aetiology or strong circumstantial evidence involvement. Polymorphisms rarer gene affecting disposition (pharmacokinetics) effect (pharmacodynamics) are discussed. In addition providing clinician useful practise therapeutics, it envisaged that increasing knowledge base will also provide a resource individuals involved biomedical research.